Major League Baseball 2K6 is a baseball video game developed by Visual Concepts and published by 2K Sports in 2006. It is the sixth game in the Major League Baseball 2K series and the only game to be published by Licensing Major League Baseball for Xbox 360 and Nintendo GameCube.
The game featured all 30 Major League Baseball teams, including the then-newest team, the Florida Marlins. The game also features a Create-a-Player mode that allows players to create their own players.
Major League Baseball 2K6 received positive reviews from critics.